Planta Med 2002; 68(8): 739-742
DOI: 10.1055/s-2002-33791
Letter
© Georg Thieme Verlag Stuttgart · New York

In vitro Inhibition of 1,3-β-Glucan Synthase by Glycolipids from Convolvulaceous Species

María V. Castelli1 , Juan C. G. Cortés2 , Andrea M. Escalante1 , Moustapha Bah3 , Rogelio Pereda-Miranda4 , Juan C. Ribas2 , Susana A. Zacchino1
  • 1Farmacognosia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina
  • 2Instituto de Microbiología Bioquímica, Campus ”Miguel de Unamuno”, C.S.I.C/Universidad de Salamanca, Salamanca, Spain
  • 3Departamento de Química y Farmacología de Productos Naturales. Facultad de Química, Universidad Autónoma de Querétaro, México
  • 4Departamento de Farmacia, Facultad de Química. Universidad Nacional Autónoma de México, Ciudad Universitaria, D.F., México
Further Information

Publication History

Received: October 11, 2001

Accepted: April 7, 2002

Publication Date:
09 September 2002 (online)

Abstract

Sixteen convolvulaceous glycolipids selected from the tricolorin (1 - 7) and orizabin (8 - 16) series, proved to be strong in vitro inhibitors of the enzyme that catalyzes the synthesis of 1,3-β-D-glucan, a major polymer of fungal cell-walls. Results provide an insight into function of the specific structures of these complex macrocyclic lactones as inhibitors of the 1,3-β-D-glucan synthase and open the possibility of using these compounds as starting points for the development of antifungal agents that act by inhibiting fungal cell-wall synthesis.

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Prof. Dra Susana A. Zacchino

Farmacognosia, Facultad Ciencias Bioquímicas y Farmacéuticas

Universidad Nacional de Rosario

Suipacha 531(2000)-Rosario

Argentina

Fax: +54-341-4375315

Email: szaabgil@citynet.net.ar