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DOI: 10.1055/s-2002-33798
© Georg Thieme Verlag Stuttgart · New York
Bioactive Constituents of the Seeds of Brucea javanica
Publication History
Received: October 30, 2001
Accepted: February 24, 2002
Publication Date:
09 September 2002 (online)
![](https://www.thieme-connect.de/media/plantamedica/200208/lookinside/thumbnails/10.1055-s-2002-33798-1.jpg)
Abstract
A new quassinoid, yadanziolide S (1), was isolated from the seeds of the traditional Chinese medicinal herb, Brucea javanica, along with ten known compounds, flazin, bruceine D, yadanziolide B, bruceoside A, yadanziolide S, yadanzigan, glycerol 1,3-bisoleate, azelaic acid, (±)-8-hydroxyhexadecanoic acid, and vanillin. Compound 1 is the first quassinoid to have been isolated from B. javanica without a methyleneoxy bridge between C-8 and C-13, and its structure was determined using spectroscopic methods, and confirmed by single-crystal X-ray diffraction. All isolates were evaluated for their potential to induce human promyelocytic leukemia (HL-60) cell differentiation, and to inhibit cyclooxygenase-1 (COX-1), -2 (COX-2), and 7,12-dimethylbenz[a]anthracene (DMBA)-induced lesions in a mouse mammary organ culture model.
Key words
Simaroubaceae - Brucea javanica - quassinoid - yadanziolide S - X-ray analysis - human promyelocytic leukemia (HL-60) - cyclooxygenase-1 (COX-1) and -2 (COX-2) - mouse mammary organ culture assay
References
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Prof. A. Douglas Kinghorn,Ph. D., D.Sc.
Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy
College of Pharmacy
University of Illinois at
Chicago
833 South Wood Street (M/C 781)
Chicago
IL 60612
U.S.A.
Phone: +1-312-996-0914
Fax: +1-312-996-7107
Email: kinghorn@uic.edu