Abstract
A facile one-pot method is presented for the synthesis of nitriles
from the corresponding primary alcohols by nickel-catalyzed oxidation
with tetrabutylammonium peroxydisulfate in the presence of ammonium
hydrogen carbonate under basic aqueous conditions. This convenient
synthetic method provides an easy and simple access to various aliphatic,
aromatic and heterocyclic nitriles in excellent yields with very
high purity.
Key words
tetrabutylammonium peroxydisulfate - nitriles - primary alcohols - oxidation
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