Cardioactive Diterpenes from the Roots of Salvia eriophora

Abstract

From the roots of Salvia eriophora (Lamiaceae), a new compound, 4,14-dihydroxysaprorthoquinone, was isolated in addition to ten known diterpenoids. The structure of the new compound was established by spectroscopic analysis. The crude extract of the plant and the isolated diterpenoids were tested for their cardiovascular activities using Wistar Albino rats. Activity was demonstrated in the crude extract and in 4,14-dihydroxysaprorthoquinone, aethiopinone, ferruginol, 4,12-dihydroxysapriparaquinone, and 6,7-dehydroroyleanone.

Key words

Salvia eriophora - Lamiaceae - abietane and rearranged abietane diterpenes - vasodepressor effect

References

• 1 Stanley P, Williams L. Fieldiana Botanica. 1973;  22 237-317
• 2 Baytop T. Therapy with Medicinal Plants in Turkey. University of Istanbul Press Istanbul; 1984: 156-8
• 3 Ulubelen A, Öksüz S, Kolak U, Birman H, Voelter W. Cardioactive terpenoids and a new rearranged diterpene from Salvia syriaca .  Planta Medica. 2000;  66 627-9
• 4 Kolak (Sönmez) U, Ari S, Birman H, Hasançebi S, Ulubelen A. Cardioactive diterpenoids from the roots of Salvia amplexicaulis .  Planta Medica. 2001;  67 671-3
• 5 Li C P, Yung K H, Chiu K W. Hypotensive action of Salvia miltiorrhiza cell culture extract.  American Journal of Chinese Medicine. 1990;  18 157-66
• 6 Boya M T, Valverde S. An orthoquinone isolated from Salvia aethiopis .  Phytochemistry. 1981;  20 1367-8
• 7 Rodriguez B, Fernandez-Gadea F, Savona G. A rearranged abietane diterpenoid from the root of Salvia aethiopis .  Phytochemistry. 1984;  23 1805-6
• 8 Mukherjee K S, Ghosh P K, Badruddoza S. Diterpenoid quinones of Salvia lanata .  Phytochemistry. 1981;  20 1441
• 9 Cambie R C, Madden R J, Parnelly J C. Chemistry of Podocarpaceae XXVIII. Constituents of some Podocarpus and other species.  Australian Journal of Chemistry. 1971;  24 217-21
• 10 Janot M M, Potier P. Identification d’une quinone isolée de l’Horminelle: Horminum pyrenaicum L. (Labiétes) a l’hydroxy-7-royléanone. P.  Annales Pharmaceutiques Françaises. 1964;  22 387-95
• 11 Edwards O E, Feniak G, Los M. Diterpenoid quinones of Inula royleana .  Can J Chem. 1962;  40 1540-6
• 12 Lin L Z, Blasko G, Cordell G A. Diterpenes of Salvia prionitis .  Phytochemistry. 1989;  28 177-81
• 13 Topcu G, Eris C, Ulubelen A. Rearranged abietane diterpenes from Salvia limbata .  Phytochemistry. 1996;  41 1143-8
• 14 Rüedi P. 8α,9α-Epoxy-7-oxoroyleanon, ein Diterpen-Epoxychinon aus einer abyssinischen Plectranthus-Art (Labiatae).  Helvetica Chimica Acta. 1984;  67 1116-20
• 15 Williams G H. Harrisons’s Principles of International Medicine 14th ed Vol. 1 1998: 1392-4
• 16 Schüssler M, Hölzl J, Fricke U. Myocardial effects of flavonoids from Crataegus species.  Drug Research. 1995;  45 842-5
• 17 Thompson E B, Aynilian G H, Gora P, Farnsworth N R. Preliminary study of potential antiarrhythmic effects of Crataegus monogyna .  Journal of Pharmaceutical Sciences. 1974;  63 1936-7
• 18 Abdalla S, Abu-Zarga M, Sabri M. Effects of the flavone luteolin, isolated from Colchicum richii, on guinea-pig isolated smooth muscle and heart and on blood pressure and blood flow.  Phytotherapy Research. 1994;  8 265-70