Planta Med 2002; 68(9): 832-833
DOI: 10.1055/s-2002-34418
Letter
© Georg Thieme Verlag Stuttgart · New York

Cucurbitacins from Trichosanthes kirilowii as the Inhibitory Components on Tyrosinase Activity and Melanin Synthesis of B16/F10 Melanoma Cells

Hyuncheol Oh1 , Yeun-Ja Mun1 , Sook-Jung Im1 , Seung Yon Lee1 , Ho Joon Song2 , Ho-Sub Lee1 , Won-Hong Woo1
  • 1Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Korea
  • 2College of Oriental Medicine, Wonkwang University, Iksan, Korea
Further Information

Publication History

Received: February 8, 2002

Accepted: May 11, 2002

Publication Date:
30 September 2002 (online)

Abstract

Cucurbitacins 1 and 2 were isolated from the root of Trichosanthes kirilowii by tyrosinase inhibitory activity-guided fractionation. Spectroscopic analysis revealed that compounds 1 and 2 were cucurbitacin D and 23,24-dihydro-cucurbitacin D, respectively. Compounds 1 and 2 effectively inhibited the activity of tyrosinase (IC50 = 0.18 μM and 6.7 μM, respectively), and the synthesis of melanin (IC50 = 0.16 μM and 7.5 μM, respectively) in B16/F10 melanoma cells.

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Prof. Won-Hong Woo

Professional Graduate School of Oriental Medicine

Wonkwang University

Iksan, Chonbuk 570-749, Korea

Email: whwoo@wonkwang.ac.kr

Fax: +82-63-850-5195