Cardiac Malformations Associated with the Holt-Oram Syndrome - Report on a Family and Review of the Literature

T. Bossert; T. Walther; J. Gummert; R. Hubald; M. Kostelka; F. W. Mohr

doi:10.1055/s-2002-34573

The Thoracic and Cardiovascular Surgeon, Table of Contents

Thorac Cardiovasc Surg 2002; 50(5): 312-314
DOI: 10.1055/s-2002-34573

Review

Cardiac Malformations Associated with the Holt-Oram Syndrome - Report on a Family and Review of the Literature

T. Bossert¹ , T. Walther¹ , J. Gummert¹ , R. Hubald¹ , M. Kostelka¹ , F. W. Mohr¹

¹Universität Leipzig, Herzzentrum, Klinik für Herzchirurgie, Germany

This paper was presented at the 3rd Joint Meeting of the German, Austrian and Swiss Societies for Thoracic and Cardiovascular Surgery in Lucerne, in February 2000

Abstract

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Abstract

The Holt-Oram syndrome (HOS) is characterized by mild-to-severe congenital cardiac defects and skeletal abnormalities of the upper limb. The most common cardiac disorder is an ostium secundum atrial septal defect (ASD), followed by ventricular septal defect (VSD) and ostium primum ASD. Electrocardiographic abnormalities, such as various degrees of atrioventricular block, have also been reported. In addition, hypoplastic peripheral vessels of the upper limbs have been observed. Here, we will report about a family with three sons having HOS, and we will detail the cardiac spectrum of HOS as reported in the literature.

Key words

Holt-Oram syndrome - Congenital heart defects - Septal defects - Limb anomalies

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References

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Torsten Bossert

Department of Cardiac Surgery, University of Leipzig Heart Center

Strümpellstr. 39

04289 Leipzig

Germany

Phone: +49 (341) 8651421

Fax: +49 (341) 8651452

Email: Tbossert11@aol.com