Isocyanatophosphoric Acid Dichloride: A Novel Reagent for the Introduction of a Cyano Group into the Molecules of Electron-Rich Heterocycles and Enamines­

Radomir V.  Smaliy; Aleksandra A.  Chaikovskaya; Aleksandr M.  Pinchuk; Andrei A.  Tolmachev

doi:10.1055/s-2002-35238

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Isocyanatophosphoric Acid Dichloride: A Novel Reagent for the Introduction of a Cyano Group into the Molecules of Electron-Rich Heterocycles and Enamines

Radomir V. Smaliy*^a, Aleksandra A. Chaikovskaya^a, Aleksandr M. Pinchuk^a, Andrei A. Tolmachev^b
^a Institute of Organic Chemistry, National Academy of Sciences of the Ukraine, Murmanska Str. 5, Kyiv-94, 02094, Ukraine
Fax: +38(44)5732643; e-Mail: iochkiev@ukrpack.net;
^b Kyiv National Taras Shevchenko University, Volodymyrska Str. 64, Ukraine

Abstract

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Abstract

A new synthetic method is developed which enables a direct one-step introduction of a cyano group into electron-rich heterocyclic systems of the indole, pyrrole, and indolizine series, and also to enamines using isocyanatophosphoryl dichloride.

Key words

nitriles - isocyanatophosphoryl dichloride - indoles - pyrroles - indolizines - enamines

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References

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Isocyanatophosphoric Acid Dichloride: A Novel Reagent for the Introduction of a Cyano Group into the Molecules of Electron-Rich Heterocycles and Enamines­

Isocyanatophosphoric Acid Dichloride: A Novel Reagent for the Introduction of a Cyano Group into the Molecules of Electron-Rich Heterocycles and Enamines