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DOI: 10.1055/s-2002-35653
© Georg Thieme Verlag Stuttgart · New York
Pughiinin A, a Sesquiterpene from the Fungus Kionochaeta pughii BCC 3878
Publication History
Received: March 8, 2002
Accepted: May 25, 2002
Publication Date:
26 November 2002 (online)
![](https://www.thieme-connect.de/media/plantamedica/200211/lookinside/thumbnails/10.1055-s-2002-35653-1.jpg)
Abstract
A novel secondary metabolite, pughiinin A, together with pycnidione, mevalonolactone, and 7-hydroxy-2-methylchromanone, was isolated from the seed fungus Kionochaeta pughii BCC 3878. The chemical structure was established by spectroscopic methods and by single crystal X-ray crystallography. Pughiinin A and pycnidione exhibited in vitro antiplasmodial activity against Plasmodium falciparum (K1 strain). Pycnidione also showed anti-cancer activity against KB and BC cell lines with the IC50 values of 2.0 and 1.6 μg/mL, respectively.
Key words
Seed fungus - antiplasmodial activity - anti-cancer activity - Kionochaeta pughii
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Dr. Pattama Pittayakhajonwut
National Center for Genetic Engineering and Biotechnology (BIOTEC)
National Science and Technology Development Agency (NSTDA)
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Email: pattamap@biotec.or.th