Planta Med 2002; 68(11): 1017-1019
DOI: 10.1055/s-2002-35653
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Pughiinin A, a Sesquiterpene from the Fungus Kionochaeta pughii BCC 3878

Pattama Pittayakhajonwut1 , Man Theerasilp2 , Palangpon Kongsaeree2 , Amporn Rungrod1 , Morakot Tanticharoen1 , Yodhathai Thebtaranonth1 , 2
  • 1National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Rajdhevee, Bangkok, Thailand
  • 2Department of Chemistry, Faculty of Science, Mahidol University, Rajdhevee, Bangkok, Thailand
Further Information

Publication History

Received: March 8, 2002

Accepted: May 25, 2002

Publication Date:
26 November 2002 (online)

Abstract

A novel secondary metabolite, pughiinin A, together with pycnidione, mevalonolactone, and 7-hydroxy-2-methylchromanone, was isolated from the seed fungus Kionochaeta pughii BCC 3878. The chemical structure was established by spectroscopic methods and by single crystal X-ray crystallography. Pughiinin A and pycnidione exhibited in vitro antiplasmodial activity against Plasmodium falciparum (K1 strain). Pycnidione also showed anti-cancer activity against KB and BC cell lines with the IC50 values of 2.0 and 1.6 μg/mL, respectively.

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Dr. Pattama Pittayakhajonwut

National Center for Genetic Engineering and Biotechnology (BIOTEC)

National Science and Technology Development Agency (NSTDA)

73/1, Rama VI Road

Rajdhevee, Bangkok 10400

Thailand

Phone: +662-6448103

Fax: +662-6448107

Email: pattamap@biotec.or.th