The High-Pressure [4+2] Cycloaddition of Activated 1,3-Dienes to Nonactivated­ Heterodienophiles Derived from Glycolaldehyde

Abstract

[4+2] Cycloaddition of 1,3-dienes to glycolaldehyde derivatives, leading to 5,6-dihydro-2H-pyrans, was effected by high pressure (10 kbar) in the presence of Eu(fod)₃ (2%). Enantioselective version of the reaction was also studied.

Key words

aldehydes - asymmetric catalysis - Diels-Alder reaction - Lewis acids - stereoselectivity

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