Postoperative Radiotherapy for Ganglioglioma; Report of Three Cases and Review of the Literature

H. C. Ulutin; Ö Öngürü; Y. Pak

doi:10.1055/s-2002-36202

min - Minimally Invasive Neurosurgery, Inhaltsverzeichnis

Minim Invasive Neurosurg 2002; 45(4): 224-227
DOI: 10.1055/s-2002-36202

Original Article

Postoperative Radiotherapy for Ganglioglioma; Report of Three Cases and Review of the Literature

H. C. Ulutin¹ , Ö. Öngürü² , Y. Pak¹

¹Department of Radiation Oncology, GATA School of Medicine, Ankara, Turkey
²Department of Pathology, GATA School of Medicine, Ankara, Turkey

Abstract

Gangliogliomas are rare tumors of the central nervous system. The definite role of postoperative radiotherapy has not been established. In studying three cases who underwent radiotherapy after subtotal resection, we evaluated the clinical, pathological, radiological features with follow-up of mean 8.1 years. All of three patients were male, and mean age was 22.3 years. All of the cases have temporal lobe lesions and, except for one, they all have seizures. Radiotherapy was given to all patients after surgery. Parallely opposed local fields were used. A total of 54 Gy in 5.5 weeks was given to the mid-plane using a Co-60 tele-therapy device. No recurrence, no new symptoms, and no new neurological deficiency were detected during follow-up.

Key words

Ganglioglioma - Sub-Total Resection - Radiotherapy

Volltext

Referenzen

References

1 Courville C B. Ganglioglioma; tumor of the central nervous system. Review of the literature and report of 2 cases. Arch Neurol Psychiatry. 1930; 24 439-491
2 Miller D C, Lang F F, Epstein F J. Central nervous system gangliogliomas. Part 1: pathology. J Neurosurg. 1993; 79 859-866
3 Zenter J, Wolf H K, Ostertun B, Hufnagel A, Campos M G, Solymosi L, Schramm J. Gangliogliomas: clinical, radiological, and histopathological findings in 51 patients. J Neurol Neurosurg Psychiatry. 1994; 57 1497-1502
4 Johannsson J H, Rekate H L, Roessmann U. Gangliogliomas: pathological and clinical correlation. J Neurosurg. 1981; 54 58-63
5 Sutton L N, Packer R J, Rorke L B, Bruce D A, Schut L. Cerebral gangliogliomas during childhood. Neurosurg. 1983; 13 124-128
6 Ventureya E, Herder S, Mallya B K, Keene D. Temporal lobe ganglioglioma in children. Childs Nerv Syst. 1986; 2 63-66
7 Lang F F, Epstein F J, Ransohoff J, Allen J C, Wisoff J, Abbot I R, Miller D C. Central nervous system gangliogliomas. Part 2: clinical outcome. J Neurosurg. 1993; 79 139-154
8 Krouwer H GJ, Davis R L, McDermott M W, Hoshino T, Prados M D. Gangliogliomas: a clinicopathological study of 25 cases and review of the literature. J Neuro-Oncol. 1993; 176 139-154
9 Castillo M, Davis P C, Takei Y, Hoffman J C. Intracranial ganglioglioma: MR, CT and clinical findings in 18 patients. AJR Am J Roentgenol. 1990; 11 109-114
10 Peritti-Viton P, Perez Castillo A M, Raybaud C, Grisoli F, Bernard F, Poncet M, Salamon G. Magnetic resonance imaging in gangliogliomas and gangliocytomas of the nervous system. J Neuroradiol. 1991; 18 189-199
11 Johnson J H, Hariharan S, Berman J, Sutton L N, Rorke L B, Molloy P, Phillips P C. Clinical outcome of pediatric gangliogliomas: ninety-nine cases over 20 years. Pediatr Neurosurg. 1997; 27 203-207
12 Poirier J, Gray F, Escourolle R. Manuel of basic neuropathology. 3^rd edition. Philadelphia: W.B. Saunders 1990
13 Silver J M, Ravlings III C E, Rossitch E, Zeidman S, Friedman A H. Ganglioglioma: a clinical study with long-term follow-up. Surg Neurol. 1991; 35 261-266
14 Kaylan-Raman U P, Olivero W C. Ganglioglioma: a correlative clinicopathological and radiographical study of ten surgically treated cases with follow-up. Neurosurgery. 1987; 20 428-433
15 Isimbaldi G, Sironi M, Tonnarelli G P, Roncoroni M, Declich P, Galli C. Ganglioglioma: a clinical and pathological study of 12 cases. Clin Neuropathol. 1996; 15 192-199
16 Pilcher W H, Silbergeld D L, Berger M S, Ojemann G A. Intraoperative electrocorticography during tumor resection: impact on seizure outcome in patients with gangliogliomas. J Neurosurg. 1993; 78 891-902
17 Hakim R, Loeffler J S, Anthony D C, Black P M. Gangliogliomas in adults. Cancer. 1997; 79 127-131
18 Haddad S F, Moore S A, Menezes A H, VanGilder J C. Ganglioglioma: 13 years of experience. Neurosurgery. 1992; 31 171-178
19 Pollack I F, Hoffman H J, Humphreys R P, Becker L. The long-term outcome after surgical treatment of dorsally exophytic brain-stem gliomas. J Neurosurg. 1993; 78 859-863
20 Dorne H L, O'Gorman A M, Melanson D. Computed tomography of intracranial ganglioglioma. AJR Am J Roentgenol. 1986; 7 281-285
21 Selch M T, Goy B W, Lee S P, El-Sadin S, Kincaid P, Park S H, Withers H R. Gangliogliomas. Experience with 34 patients and review of the literature. Am J Clin Oncol. 1998; 21 557-564
22 Russel D S, Rubinstein L J. Ganglioglioma: a case with long history and malignant evaluation. J Neuropathol Exp Neurol. 1962; 21 185-193
23 Burger P C, Scheithauer B W. Tumors of the central nervous system. 3rd series. Washington D.C. Armed Forces Institute of Pathology 1994: 163-175
24 Hirose T, Kannuki S, Nishida K, Matsumoto K, Sano T, Hizawa K. Anaplastic ganglioglioma of the brain stem demonstrating active neurosecretory features of neuronal cells. Acta Neuropathol (Berl). 1992; 83 365-370
25 Celli P, Scarpinati M, Nardacci L, Cervoni L, Gantore G P. Gangliogliomas of the cerebral hemisphere. Report of 14 cases with long-term follow-up and review of the literature. Acta Neurochir (Wien). 1993; 125 52-57
26 Yasargil M G, von Ammon K, von Deimling A, Valavanis A, Wichmann W, Wiestler O D. Central neurocytoma: histopathological variants and therapeutic approaches. J Neurosurg. 1992; 76 32-37
27 Demierre B, Stichnoth F A, Hori A, Spoerri O. Intracerebral ganglioglioma. J Neurosurg. 1986; 65 177-182
28 Castillo M, Davis P C, Takei Y, Hoffman J C. Intracranial ganglioglioma: MR, CT, and clinical findings in 18 patients. AJR. 1990; 154 607-612
29 Cox J D, Zimmerman H M, Haughton V M. Microcystic ganglioglioma treated by partial removal and radiation therapy. Cancer. 1982; 50 473-477
30 Kitano M, Takayama S, Nagao T, Yoshimura O. Malignant ganglioglioma of the spinal cord. Acta Pathology Japan. 1987; 37 1009-1018
31 Wackler M R, Cogen P H, Etzell J E, Daneshvar L, Davis R L, Prados M D. Diffuse leptomeningeal involvement by a ganglioglioma in a child. J Neurosurg. 1992; 77 302-306
32 Rumana C S, Valadka A B. Radiation therapy and malignant degeneration of supratentorial gangliogliomas. Neurosurgery. 1998; 42 1038-1043
33 Jay V, Squire J, Becker L E, Humphreys R. Malignant transformation in a ganglioglioma with anaplastic neuronal and astrocytic components. Report of a case with flow cytometric and cytogenetic analysis. Cancer. 1994; 73 2862-2868

Dr. C. Ulutin

GATA Lojmanları Ural apt.

Daire 39

Etlik 06018

Ankara

Turkey

eMail: culutin@yahoo.com