Abstract
The β-amino acid BAY 10-8888/PLD-118 is currently being
investigated in phase II clinical studies as a novel antifungal for
the treatment of yeast infections. An efficient asymmetric synthesis
of this compound is described. The key step employed a highly enantioselective,
quinine-mediated alcoholysis of a meso -anhydride
intermediate.
Key words
amino acids - antifungal agents - asymmetric
synthesis - desymmetrization - quinine
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