Planta Med 2003; 69(1): 63-64
DOI: 10.1055/s-2003-37024
Letter
© Georg Thieme Verlag Stuttgart · New York

Lignans with Inhibitory Activity against NFAT Transcription from Schisandra chinensis

Im Seon Lee1 , Hyeong-Kyu Lee2 , Nguyen Tien Dat1 , Mi Sun Lee3 , Jung Woo Kim3 , Doe Sun Na4 , Young Ho Kim1
  • 1College of Pharmacy, Chungnam National University
  • 2Immunomodulator Research Laboratory, Korea Research Institute of Bioscience and Biotechnology
  • 3Bio-Med RRC, Division of Life Sciences, Pai Chai University, Daejeon, Korea
  • 4University of Ulsan College of Medicine, Seoul 138-736, Korea
Further Information

Publication History

Received: April 19, 2002

Accepted: July 31, 2002

Publication Date:
04 February 2003 (online)

Abstract

Seven lignans from Schisandra chinensis were investigated for their inhibitory activity on NFAT transcription. Both gomisin N (IC50 : 1.33 ± 0.05 μM) and schisandrol A (IC50 : 1.34 ± 0.05 μM) showed higher activity than gomisin E (IC50 : 4.73 ± 0.09 μM), schisandrin A (IC50 : 7.23 ± 0.21 μM), schisandrin C (IC50 : 7.54 ± 0.22 μM), benzoylisogomisin O (IC50 : 11.06 ± 1.02 μM) and schisandrol B (IC50 : 16.37 ± 1.00 μM).

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Young Ho Kim, Ph. D.

College of Pharmacy

Chungnam National University

Daejeon, 305-764, Korea

Phone: +82-42-821-5933

Fax: +82-42-823-6566

Email: yhk@cnu.ac.kr