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Planta Med 2003; 69(1): 63-64
DOI: 10.1055/s-2003-37024
Letter
© Georg Thieme Verlag Stuttgart · New York

Lignans with Inhibitory Activity against NFAT Transcription from Schisandra chinensis

Im Seon Lee1 , Hyeong-Kyu Lee2 , Nguyen Tien Dat1 , Mi Sun Lee3 , Jung Woo Kim3 , Doe Sun Na4 , Young Ho Kim1
  • 1College of Pharmacy, Chungnam National University
  • 2Immunomodulator Research Laboratory, Korea Research Institute of Bioscience and Biotechnology
  • 3Bio-Med RRC, Division of Life Sciences, Pai Chai University, Daejeon, Korea
  • 4University of Ulsan College of Medicine, Seoul 138-736, Korea
Further Information

Publication History

Received: April 19, 2002

Accepted: July 31, 2002

Publication Date:
04 February 2003 (online)

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Abstract

Seven lignans from Schisandra chinensis were investigated for their inhibitory activity on NFAT transcription. Both gomisin N (IC50 : 1.33 ± 0.05 μM) and schisandrol A (IC50 : 1.34 ± 0.05 μM) showed higher activity than gomisin E (IC50 : 4.73 ± 0.09 μM), schisandrin A (IC50 : 7.23 ± 0.21 μM), schisandrin C (IC50 : 7.54 ± 0.22 μM), benzoylisogomisin O (IC50 : 11.06 ± 1.02 μM) and schisandrol B (IC50 : 16.37 ± 1.00 μM).

References

  • 1 Winter G, Harris W J. Humanized antibodies.  Immunology Today. 1993;  14 243-6
    CrossrefPubMedGoogle Scholar
  • 2 Abbas A K, Lichtman A H, Pober J S. Cellular and molecular immunology. W.B. Saunders Company Philadelphia; 1997: 315-38
    Google Scholar
  • 3 Aramburu J, Yaffe M B, Lopez-Rodriguez C, Cantly L C, Horgan P G, Rao A. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.  Science. 1999;  285 2129-33
    CrossrefPubMedGoogle Scholar
  • 4 Djuric S W, BaMaung N Y, Basha A, Liu H, Luly J R, Madar D J, Sciotti R J, Tu N P, Wagenaar F L, Wiedeman P E, Zhou X, Ballaron S, Bauch J, Chen Y -W, Chiou X G, Fey T, Gauvin D, Gubbins E, Hsieh G C, Marsh K C, Mollison K W, Pong M, Shaughnessy T K, Sheets M P, Smith M, Trevillyan J M, Warrior U, Wegner C D, Carter G W. 3,5-Bis(trifluoromethyl)pyrazoles: A novel class of NFAT transcription factor regulator.  Journal of Medicinal Chemistry. 2000;  43 2975-81
    CrossrefPubMedGoogle Scholar
  • 5 Lee I S, Jung K Y, Oh S R, Park S H, Ahn K S, Lee H -K. Structure-activity relationships of lignans from Schisandra chinensis as platelet activating factor antagonist.  Biological and Pharmaceutical Bulletin. 1999;  22 265-7
    PubMedGoogle Scholar
  • 6 Bensky D, Gamble A. Materia medica. Eastland press Washington; 1986: 376-8
    Google Scholar
  • 7 Chen Y -Y, Shu T P, Li L L. Studies on Fructus schizandrae. IV. Isolation and determination of the active compounds (in lowering high SGPT [serum glutamic-pyruvic transaminase] levels) of Schizandra chinensis Baill. Sci.  Sin. 1976;  19 276-90
    PubMedGoogle Scholar
  • 8 Yang T T, Sinai P, Kitts P A, Kain S R. Quantification of gene expression with a secreted alkaline phosphatase reporter system.  Biotechniques. 1997;  23 1110-4
    PubMedGoogle Scholar
  • 9 Jain J, Loh C, Rao A. Transcriptional regulation of the IL-2 gene.  Current Opinion in Immunology. 1995;  7 333-42
    CrossrefPubMedGoogle Scholar

Young Ho Kim, Ph. D.

College of Pharmacy

Chungnam National University

Daejeon, 305-764, Korea

Phone: +82-42-821-5933

Fax: +82-42-823-6566

Email: yhk@cnu.ac.kr