Synthesis of Pyridine-Fused Ring Systems from β-Chloroacroleins: A Comparison­ of Three Different Pathways

Abstract

Three different pathways for the access of pyridine-fused ring systems are described: 1) a Sonogashira coupling of β-chloroacroleins followed by cyclization of the corresponding imines; 2) the same coupling reaction followed by cyclization of the corresponding oximes; and 3) a palladium-catalyzed iminoannulation of internal alkynes.

β-chloroacroleins - Sonogashira coupling - heteroannulation - imines

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