Synthesis of β-Amino and β-Hydroxy Phosphonates

Abstract

Two alternative routes to methyl and trifluoromethyl substituted β-amino and β-hydroxy phosphonates via hydrogenation of vinylphosphonates and via aldol-type addition of ethylphosphonate to trifluoromethyl substituted imines and carbonyl compounds are described.

Key Words

hydrogenation - aldol reactions - fluorinated imines - fluorinated ketones - phosphonates

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