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Planta Med 2003; 69(4): 361-366
DOI: 10.1055/s-2003-38875
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Three New Jatrophane-Type Diterpenes from Euphorbia pubescens

Cláudia Valente1 , Maria José U. Ferreira1 , Pedro M. Abreu2 , Madalena Pedro3 , Fátima Cerqueira3 , Maria São José Nascimento3
  • 1Centro de Estudos de Ciências Farmacêuticas, Faculdade de Farmácia da Universidade de Lisboa, Lisboa, Portugal
  • 2CQFB/REQUIMTE, Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa, Caparica, Portugal
  • 3Centro de Estudos de Química Orgânica, Fitoquímica e Farmacologia da Universidade do Porto, Faculdade de Farmácia, Porto, Portugal
Further Information

Publication History

Received: August 5, 2002

Accepted: November 23, 2002

Publication Date:
23 April 2003 (online)

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Abstract

Three new macrocyclic jatrophane diterpene polyesters, named pubescenes A (1), B (2), and C (3), and the known compounds indole-3-aldehyde and scopoletin have been isolated and characterised from the whole dried plant of Euphorbia pubescens. The structures of the new compounds were established by spectroscopic means including 2D-NMR techniques such as COSY, HMQC, HMBC and NOESY experiments. Compounds 1 - 3 were evaluated for their in vitro effect on the growth of three human cancer cell lines MCF-7 (breast), NCI-H460 (lung) and SF-268 (CNS) as well as for their capacity to interfere with the proliferation of human peripheral blood lymphocytes. They exhibited a moderate growth inhibitory effect on the cancer cell line NCI-H460. No effect was observed on the mitogenic response of human lymphocytes to PHA.

Key words

Euphorbia pubescens - Euphorbiaceae - jatrophane diterpenes - antitumour

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Prof. Maria José Umbelino Ferreira

Centro de Estudos de Ciências Farmacêuticas

Faculdade de Farmácia da Universidade de Lisboa

Av. das Forças Armadas

1600-083 Lisboa

Portugal

Email: mjuferreira@ff.ul.pt

Fax: +351-21-7946470