Horm Metab Res 2003; 35(4): 201-203
DOI: 10.1055/s-2003-39474
Hypothesis
© Georg Thieme Verlag Stuttgart · New York

Is Hypercortisolaemia a Factor in Chronic Fatigue Syndrome?

M.  J.  Renan1
  • 1Division of Medical Microbiology, Health Sciences Faculty, University of Cape Town, South Africa
Further Information

Publication History

Received 4 November 2002

Accepted after Revision 28 November 2002

Publication Date:
02 June 2003 (online)

References

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  • 2 Orth D N, Kovacs W J. 1998 The adrenal cortex. In: Williams textbook of Endocrinology, 9th Edition. Wilson JD, Foster DW, Kronenberg HM, Larsen PR, eds. Philadelphia; Saunders Publishing Co, Chap. 12
  • 3 van Praag H M. Faulty cortisol/serotonin interplay.  Psychiatry Res. 1996;  65 143-157
  • 4 Snyder S H. Serotonin sustains serenity.  Nature. 2002;  416 377-380
  • 5 McCann S M, Karanath S, Kamat A. et al .1995 Role of cytokines in hypothalamic-pituitary functions. In: Human cytokines, their role in disease and therapy. Aggarwal BB, Puri RK, eds Blackwell Press, Chap. 18
  • 6 Fukuda K. The chronic fatigue syndrome: a comprehensive approach to its definition and study. International chronic fatigue study group.  Ann Intern Med. 1994;  121 953-959
  • 7 Landay A L, Jessop C, Lennette E T, Levy J A. Chronic fatigue syndrome: clinical condition associated with immune activation.  Lancet. 1991;  338 707-712
  • 8 Demitrack M A, Dale J K, Strauss S E. et al . Evidence for impaired activation of the hypothalamic-pituitary-adrenal axis in patients with chronic fatigue syndrome.  J Clin Endocrinol Metab. 1991;  73 1224-1234
  • 9 Komaroff A L. The biology of chronic fatigue syndrome.  Am J Med. 2000;  108 169-171
  • 10 Cleare A J, Heap E, Malhi G. et al . Low-dose hydrocortisone in chronic fatigue syndrome; a randomised crossover trial.  Lancet. 1999;  353 455-458
  • 11 Caruso I, Sarzi-Puttini P, Cazzola M, Azzolini V. Double-blind study of 5-hydroxytyptophan versus placebo in the treatment of primary fibromyalgia syndrome.  J Internat Med Res. 1990;  18 201-209

M. J. Renan, Ph. D.

Division of Medical Microbiology · Health Sciences Faculty · University of Cape Town · Observatory

Cape Town 7925 · South Africa ·

Phone: +21 (406) 63 63

Fax: +21 (448) 81 53

Email: mrenan@curie.uct.ac.za