Microwave-Assisted One-Pot Synthesis of 2,4-Disubstituted Quinolines under Solvent-Free Conditions

Abstract

Aromatic imines derived in situ from aryl aldehydes and aryl amines undergo smoothly, cyclization with alkynes on the surface of montmorillonite clay impregnated with copper(I) bromide under solvent-free conditions to produce 2,4-disubstituted quinolines in high yields with excellent selectivity. The reaction rates and yields are significantly improved by employing microwave irradiation.

Key words

microwave - aryl imines - alkynes - substituted quinolines

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