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Synthesis 2003(11): 1639-1642
DOI: 10.1055/s-2003-40871
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

The Application of Asymmetric Hydrogenation for the Manufacture of Pharmaceutical­ Intermediates: The Need for Catalyst Diversity

Ian C. Lennon*, Christopher J. Pilkington*
Dowpharma, Chirotech Technology Ltd, A Subsidiary of The Dow Chemical Company, Unit 321, Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, UK
Fax: +44(1223)506701; e-Mail: ilennon@dow.com;
Further Information

Publication History

Received 28 April 2003
Publication Date:
25 July 2003 (online)

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Abstract

Asymmetric hydrogenation is becoming an increasingly prevalent technology for the manufacture of complex pharmaceutical intermediates. Drawing from Chirotech’s experience over the past eight years, this article emphasises the need for a diverse catalyst collection in providing practical solutions for a wide range of target compounds.

Key words

asymmetric hydrogenation - diversity - DuPhos - ligands - catalyst collection

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