One-Pot Synthesis of 3-Carboxycoumarins via Consecutive Knoevenagel and Pinner Reactions in Water

Francesco Fringuelli; Oriana Piermatti; Ferdinando Pizzo

doi:10.1055/s-2003-41061

PAPER

One-Pot Synthesis of 3-Carboxycoumarins via Consecutive Knoevenagel and Pinner Reactions in Water

Francesco Fringuelli, Oriana Piermatti*, Ferdinando Pizzo*
Dipartimento di Chimica, Università di Perugia, Via Elce di Sotto 8, 06123 Perugia, Italy
e-Mail: pizzo@unipg.it;

Abstract

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Abstract

Chloro-, hydroxy-, methoxy-, and tert-butyl-substituted 3-carboxycoumarins have been prepared by one-pot procedure by reaction of suitably substituted salicylaldehydes with malononitrile in water. The over-all yields are high and the protocol does not require organic solvents.

Key words

aldol reactions - cyclizations - hydrolyses - 3-carboxycoumarins - water

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