Vanadium(III) Chloride-Catalyzed Preparation of β-Amino Alcohols from Epoxides

Abstract

Vanadium(III) chloride was found to catalyze the cleavage of epoxides with aromatic amines in an efficient way to afford the corresponding β-amino alcohols in very good yields. The reactions are completely anti-stereoselective, highly regioselective and proceed at room temperature.

epoxides - amines - VCl₃ - amino alcohols

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