Synlett 2003(11): 1655-1658
DOI: 10.1055/s-2003-41424
LETTER
© Georg Thieme Verlag Stuttgart · New York

High-Pressure-Promoted Asymmetric Aldol Reactions of Ketones with Aldehydes Catalyzed by l-Proline [1]

Yusuke Sekiguchi, Aika Sasaoka, Ai Shimomoto, Shingo Fujioka, Hiyoshizo Kotsuki*
Laboratory of Natural Products Synthesis, Faculty of Science, Kochi University, Akebono-cho, Kochi 780-8520, Japan
Fax: +81(88)8448359; e-Mail: kotsuki@cc.kochi-u.ac.jp;
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Publication History

Received 26 June 2003
Publication Date:
22 September 2003 (online)

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Abstract

High-pressure conditions were applied to direct asymmetric aldol reactions between ketones and aldehydes with l-proline as a commercially available chiral amino acid catalyst.

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