Biographical Sketches
K. Pasupathy completed his Bachelor (BSc, 1996) and Masters (M. Sc, 1998) degree in
chemistry from Sri Sathya Institute of Higher Learning, Puttaparthy, India. He is
currently working as a CSIR-SRF for his PhD degree under the supervision of Dr. S.
P. Chavan at the Division of Organic chemistry (Technology) National Chemical Laboratory,
Pune, India.
Introduction
Introduction <P>Mg/MeOH has proved to be a very useful reagent for various organic transformations.
All the organic transformations using this reagent are carried out at room temperature.
Anhydrous methanol is used for the reactions involving Mg/MeOH. The mildness, ease
of availability of magnesium, both commercially and its natural abundance, coupled
with convenient reaction conditions makes this reagent a useful choice over other
methods which are expensive, toxic, and inconvenient. These aspects of this reagent
are exemplified in the reductive cyclization of activated dienes where toxic and expensive
reagents such as Bu3 SnH and SmI2 are used.</P>
Abstract
Abstract
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(A) Treatment of akyl and aryl touene sulfonates with Mg/MeOH constitutes an ideal
procedure for regeneration of corresponding alcohols through S-O bond cleavage.
[1 ]
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(B) Mg or Ca/MeOH provides a facile method for the reduction of alkyl and aryl azides
to the corresponding amines.
[2 ]
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(C) Desulfonylation of chiral N-sulfonyl aziridines to the corresponding aziridines
is carried in a mild and facile manner by Mg/MeOH.
[3 ]
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(D) Mg/MeOH offers an efficient, convenient, and selective methodology for reduction
of a,b-unsaturated esters, nitriles, amides, lactams etc in the presence of a nonconjugated
double bond.
[4a-d ]
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(E) When activated tethered dienes were subjected to treatment with Mg/MeOH at room
temperature, facile conversion to carbocycles and heterocycles occurred in good yields.
[5 ]
[6 ]
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