Ammonium Cerium(IV) Nitrate as an Efficient Oxidizing Agent for Fused 1,4-Dihydropyridazine Derivatives and Hydrazides

Franc Požgan; Slovenko Polanc; Marijan Kočevar

doi:10.1055/s-2003-42413

PAPER

Ammonium Cerium(IV) Nitrate as an Efficient Oxidizing Agent for Fused 1,4-Dihydropyridazine Derivatives and Hydrazides

Franc Požgan, Slovenko Polanc, Marijan Kočevar*
Faculty of Chemistry and Chemical Technology, University of Ljubljana, Akerč eva 5, 1000 Ljubljana, Slovenia
Fax: +386(1)2419220; e-Mail: marijan.kocevar@uni-lj.si;

Abstract

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Abstract

A simple method for the aromatization of a fused 1,4-dihydropyridazine ring as well as a concomitant oxidation of a carbohydrazido group into the corresponding esters is presented. In particular, 1,4,6,7,8,9-hexahydro-5H-pyridazino[4,3-c]azepine-3-carboxylic acid hydrazides 1 are rapidly oxidized using six equivalents of ammonium cerium(IV) nitrate (CAN) in different alcohols to the corresponding fused pyridazine esters 3.

Key words

heterocycles - dehydrogenations - esters - oxidations - ammonium cerium(IV) nitrate - fused pyridazines

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References

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