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Synthesis 2003(18): 2781-2784
DOI: 10.1055/s-2003-42453
DOI: 10.1055/s-2003-42453
PAPER
© Georg Thieme Verlag Stuttgart · New York
Synthesis of New 4-Nitrosophenyl-1,4-dihydropyridines of Pharmacological Interest
Further Information
Received
28 July 2003
Publication Date:
23 October 2003 (online)
Publication History
Publication Date:
23 October 2003 (online)
Abstract
The synthesis and characterization of a series of 4-nitrosophenyl-1,4-dihydropyridines derived from the respective nitro compounds of pharmacological interest is described. The complete synthetic pathway is based on the classical Hantzsch 1,4-dihydropyridine synthesis to obtain the nitrophenyl 1,4-dihydropyridines in a first step, followed by chemical reduction of the nitro compound to the corresponding hydroxylamine and further oxidation to the nitroso derivative. The synthesis and characterization of the compounds is described.
Key words
Hantzsch synthesis - pyridines - reductions - drugs - nitroso compounds
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