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Synthesis 2003(18): 2851-2857  
DOI: 10.1055/s-2003-42458
PAPER
© Georg Thieme Verlag Stuttgart · New York

A Facile Synthesis of Derivatives of (1,3,4-Thiadiazol-2-yl)glycine and Its Phosphonyl Analogue

Aleksandr V. Golovchenkoa, Stepan G. Pilyoa, Vladimir S. Brovarets*a, Alexander N. Chernegab, Boris S. Dracha
a Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, Murmanska str. 1, Kyiv-94, 02094, Ukraine
Fax: +380(44)5732561; e-Mail: Drach@bpci.kiev.ua;
b Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmanska str. 5, Kyiv-94, 02094, Ukraine
Fax: +380(44)5732643;
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Publikationsverlauf

Received 23 July 2003
Publikationsdatum:
04. November 2003 (online)

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Abstract

The adducts formed by 4-functionally-substituted 2-aryl-5-hydrazino-1,3-oxazoles and aryl isothiocyanates recyclize on heating to produce the hitherto unknown derivatives of (1,3,4-thiadiazol-2-yl)glycine and its phosphonyl analogue.

Key words

α-aminocarboxylic acids - α-aminoalkylphosphonic acids - (1,3,4-thiadiazol-2-yl)glycine - 1,3-oxazoles - 3,3-dichloroacrylates - 2,2,2-trichloroethylphosphonates - aryl isothiocyanates

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Full crystallographic details have been deposited at Cambridge Crystallographic Data Centre (CCDC). Any request to the CCDC for this material, should quote the full literature citation and reference number CCDC 215589.