New Eremophilane Sesquiterpenes from Cacalia ainsliaeflora

Manjun Mao; Zhongduo Yang; Zhongjian Jia

doi:10.1055/s-2003-42793

Planta Medica, Table of Contents

Planta Med 2003; 69(8): 745-749
DOI: 10.1055/s-2003-42793

Original Paper

Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

New Eremophilane Sesquiterpenes from Cacalia ainsliaeflora

Manjun Mao^1, ² , Zhongduo Yang¹ , Zhongjian Jia¹

¹Department of Chemistry, National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, P.R. China
²Department of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, P.R. China

This work was supported by the Research and Development Foundation of Shanghai-SK No.2002013-t and the National Natural Science Foundation of China No.29972017

Abstract

One known eremophilanolide, 3β-angeloyloxy-8β,10β-dihydroxy-6β-methoxyeremophilenolide (1) and seven new eremophiane sesquiterpenes, 3β-angeloyloxy-6β-ethoxy-8β,10β-dihydroxyeremophilenolide (2), 3β,6β-diangeloyloxy-10α-hydroxy-8α-methoxyeremophilenolide, 6β-angeloyloxy-8β,10β-dihydroxy-3-oxo-eremophilenolide, 6β,8β,10β-trihydroxy-3-oxo-eremophilenolide, 3β-angeloyloxy-6β,10β-dihydroxy-eremophila-7(11),8(9)-dien-8,12-olide (6), 3β-angeloyloxy-10β-hydroxy-6β-methoxy-eremophila-7(11),8(9)-dien-8,12-olide, 3β-angeloyloxy-8-oxo-eremophila-6.9-dien-12-oic acid ethyl ester, were isolated from the roots of Cacalia ainsliaeflora. Their structures were elucidated by spectroscopic methods. Compounds 1, 2 and 6 were assayed against both Gram-positive and Gram-negative bacteria. No positive activities were observed.

Key words

Cacalia ainsliaeflora - Compositae - eremophilane sesquiterpenes

Full Text

References

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Prof. Zhong-Jian Jia

Department of Chemistry

Lanzhou University

Lanzhou 730000

People’s Republic of China

Fax: +86-0931-8912582

Email: Jiazj@lzu.edu.cn