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Planta Med 2003; 69(9): 842-845
DOI: 10.1055/s-2003-43215
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Cytotoxic Alkaloids from Boehmeria siamensis

Yinggang Luo1 , 2 , Yan Liu3 , Dixiang Luo3 , Xiaoping Gao3 , Bogang Li1 , Guolin Zhang1
  • 1Chengdu Institute of Biology, the Chinese Academy of Sciences, Chengdu, P. R. China
  • 2Chengdu Institute of Organic Chemistry, the Chinese Academy of Sciences, Chengdu, P. R. China
  • 3Pharmaceutical Institute of Di-Ao Pharmaceutical Group, Chengdu, P. R. China
Further Information

Publication History

Received: December 27, 2002

Accepted: March 29, 2003

Publication Date:
04 November 2003 (online)

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Abstract

Two new phenanthroquinolizidine alkaloids, boehmeriasins A and B, were isolated from the aqueous ethanolic extract of Boehmeria siamensis Craib (Urticaceae) by bioassay-guided fractionation. Their structures were elucidated on the basis of spectral evidence. Boehmeriasin A possesses cytotoxic activity against 12 cell lines from 6 panels of cancer including lung cancer, colon cancer, breast cancer, prostate cancer, kidney cancer and leukemia with GI50 between 0.2 and 100 ng/mL, whereas boehmeriasin B showed lower activity.

Key words

Boehmeria siamensis - Urticaceae - boehmeriasin A - boehmeriasin B - cytotoxic activity

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Prof. Dr. Guolin Zhang

Chengdu Institute of Biology

The Chinese Academy of Sciences

P. O. 416

Chengdu 610041

P. R. China

Phone: /Fax: +86-28-85225401

Email: Zhanggl@cib.ac.cn