New Guaianolides from Leaves and Stems of Chrysanthemum boreale

Abstract

The 8-acetoxy-2-methoxy-10-hydroxy-3,11(13)-guaiaden-12,6-olide 1 and 8,10-diacetoxy-2-methoxy-3,11(13)-guaiadiene-12,6-olide 2 were isolated from Chrysanthemum boreale Makino. Compound 1 inhibited the etoposide-induced apoptosis in U 937 cells with an IC₅₀ value 8.6 μg/mL.

References

• 1 Willuhn G. Arnica flowers: Pharmacology, toxicology, and analysis of the sesquiterpene lactones-their main active substances. In: Lawson LD, Bauer R, editors Phytomedicines of Europe. Washington DC; American Chemical Society 1998: pp. 118-32
• 2 Encyclopedia of the Traditional Chinese Materia Medica. Shanghai; People’s Press 1977: p. 2128
• 3 He Y Q, Li R Z, S’hen L. Separation and identification of flavonoids from the flower of Chrysantheum indicum .  Peiching Hsueh Yuan Hsueh Pao. 1982;  14 259-61
• 4 Bohlmann F, Arnot C, Bornowski H. Polyacetylene compounds. Part 28. Several polyacetylenes from the tribe Anthemideae L.  Chem Ber. 1960;  93 1937-44
• 5 Lee J R, Yang M S, Jang D S, Ha T J, Park K M, Lee C H, Kho Y H, Park K H. A new guaianolide as apoptosis inhibitor from Chrysanthemum boreale .  Planta Med. 2001;  67 585-7
• 6 Nikolaus H F. Sesquiterpenoid lactones, Vol. 7. In: 5. Charlwood BV, Banthorpe DV, editors Methods in plant biochemistry Harcourt Brace Jovanovich. San Diego; Academic press 1991: pp. 187-211
• 7 Tsai J C, Jain M, Hsieh C M, Lee W S, Yoshizumi M, Patterson C. et al . Induction of apoptosis by pyrrolidinedithiocarbamate and N-acetylcysteine in vascular smooth muscle cells.  J Biol Chem. 1996;  271 3667-70
• 8 Grutu V, Kain S R, Zhang G. Fluorometric and colorimetric detection of caspase activity associated with apoptosis.  Analytical Biochemistry. 1997;  251 98-102
• 9 Skehan P, Storeng R, Scudiero D, Monks A, McMahon J, Vistica D. et al . New colorimetric cytotoxicity assay for anticancer-drug screening.  Journal National Cancer Institute. 1990;  82 1107-12