Int J Sports Med 2003; 24(8): 620-627
DOI: 10.1055/s-2003-43293
Physiology & Biochemistry
© Georg Thieme Verlag Stuttgart · New York

Nandrolone Progress Report to the UK Sports Council from the Expert Committee on Nandrolone February 2003

A.  Kicman
Further Information

Publication History

Publication Date:
04 November 2003 (online)

References

  • 1 Catlin D H, Leder B Z, Ahrens B, Starcevic B, Hatton C K, Green G A, Finkelstein J S. Trace contamination of over-the-counter androstenedione and positive urine test results for a nandrolone metabolite.  JAMA. 2000;  284 2618-2621
  • 2 Court of Arbitration Award TAS 98/212. 
  • 3 Court of Arbitration Award TAS 98/222. 
  • 4 Court of Arbitration Award TAS 99/A/234 and 235. 
  • 5 Davis S. A brief review of nandrolone doping control procedures. Web site address for article: http://ourworld.compuserve.com/homepages/SimonDavis1/Nandro.html date last accessed 12 December 2002
  • 6 De Wasch K, Le Bizec B, De Brabander H, Andre F, Impens S. Consequence of boar edible tissue consumption on urinary profiles of nandrolone metabolites. II. Identification and quantification of 19-norsteroids responsible for 19-norandrosterone and 19-noretiocholanolone excretion in human urine.  Rapid Commun Mass Spectrom. 2001;  15 1442-1447
  • 7 Debruyckere G, de Sagher R, de Leenheer A, Van Peteghem C. In: Gorog S, ed Advances of Steroid Analysis, Proceedings of the 4th Symposium on the Analysis of Steroids, Pecs, Hungary. Budapest. Akademiai Kiado 1991: 363-370
  • 8 Debruyckere G, Van Peteghem C H, de Sagher R. Influence of the Consumption of Meat Contaminated with Anabolic-Steroids on Doping Tests.  Anal Chim Acta. 1993;  275 49-56
  • 9 Desroches M C, Mathurin J C, Richard Y, Delahaut P, de Ceaurriz J. Urinary 19-norandrosterone purification by immunoaffinity chromatography: application to gas chromatography/combustion/isotope ratio mass spectrometric analysis.  Rapid Commun Mass Spectrom. 2002;  16 370-374
  • 10 Forschungsberichte: “Untersuchung auf mögliche Verunreinigungen von Nahrungsergänzungsmitteln (Verzehrprodukte) mit anabolen Steroiden (chemische Analyse, gegebenenfalls toxikologische Risikobewertung)”; ARC Seibersdorf research GmbH, Bundesministerium für soziale Sicherheit und Generationen, Sektion IX - Abteilung 9, Radetzkystraße 2, 1031 WIEN. Access web page via www.dopinginfo.de, then click on the title “Institut fur Biochemie”, then select “Nahrungsergänzungsmittel” followed by “Firmen- und Produktnamen”. Date last accessed 13 December 2002
  • 11 Galan Martin AM, Maynar Marino JI, Garcia de Piedra MP, Rivero Marabe JJ, Caballero Loscos MJ, Maynar Marino M. Determination of nandrolone and metabolites in urine samples from sedentary persons and sportsmen.  J Chromatogr B. 2001;  761 229-236
  • 12 Geyer H, Mareck-Engelke U, Reinhart U, Thevis M, Schanzer W. Positive dopingfalle mit norandrosteron durch verunreinigte nahrungserganzungsmittel.  Dtsch Z Sportsmed. 2000;  51 378-382
  • 13 Hemmersbach P. Personal communication to Nandrolone Review Committee; Urinary concentrations of 19-norandrosterone in samples collected at the XVII Winter Olympic Games in 1994. Hormone Laboratory, Aker University Hospital, Section for Doping Analysis, Oslo, Norway letter dated 20 April 2001
  • 14 IAAF - Details of the Merlene Ottey Decision (7 July 2000) - access via http://www.iaaf.org (select “News” then “Search” using search term “Ottey Decision”,. date last accessed 12 December 2002
  • 15 IOC nutritional supplements study points to need for greater quality control .Access web page via http://www.olympic.org (under “Ask a question” type “nutritional supplements” and then select the press release on 04 April 2002) date last accessed 12 December 2002
  • 16 Kohler R MN, Lambert M I. Urine nandrolone metabolites: false positive doping test.  Br J Sports Med. 2002;  36 325-329
  • 17 Le Bizec B, Bryand F, Gaudin I, Monteau F, Poulain F, Andre F. Endogenous nandrolone metabolites in human urine: preliminary results to discriminate between endogenous and exogenous origin.  Steroids. 2002;  67 105-110
  • 18 Le Bizec B, Bryand F, Gaudin I, Monteau F, Poulain F, Andre F. Endogenous nandrolone metabolites in human urine. Two-year monitoring of male professional soccer players.  J Anal Toxicol. 2002;  26 43-47
  • 19 Le Bizec B, Gaudin I, Monteau F, Andre F, Impens S, De Wasch K, De Brabander H. Consequence of boar edible tissue consumption on urinary profiles of nandrolone metabolites. I. Mass spectrometric detection and quantification of 19-norandrosterone and 19-noretiocholanolone in human urine.  Rapid Commun Mass Spectrom. 2000;  14 1058-1065
  • 20 Le Bizec B, Monteau F, Gaudin I, Andre F. Evidence for the presence of endogenous 19-norandrosterone in human urine.  J Chromatogr B. 1999;  723 157-172
  • 21 Mareck-Engelke U, Schultze G, Geyer H, Schanzer W. The appearance of urinary 19-norandrosterone during pregnancy.  Eur J Sports Sci. 2002;  2 1-7
  • 22 Mathurin J C, Herrou V, Bourgogne E, Pascaud L, de Ceaurriz J. Gas chromatography-combustion-isotope ratio mass spectrometry analysis of 19-norsteroids: application to the detection of a nandrolone metabolite in urine.  J Chromatogr B. 2001;  759 267-275
  • 23 Misuse of Drugs legislation - Proposed changes. Letter (4 March 2002),. access via http://homeoffice.gov.uk/oicd/letter.htm (then select “Letter” date last accessed 12 December 2002
  • 24 Olympic Movement Anti-Doping Code, Appendix -1. Prohibited classes of substances and prohibited methods. Access via http://www.olympic.org (under “Ask a question” type “Anti-Doping Code”) date last accessed 12 December 2002
  • 25 Reeb M. Personal communication to the Nandrolone Review Committee. Acting Secretary, General Court of Arbitration for Sport letter dated 19 March 2001
  • 26 Reznik Y, Dehennin L, Coffin C, Mahoudeau J, Leymarie P. Urinary nandrolone metabolites of endogenous origin in man: A confirmation by output regulation under human chorionic gonadotropin stimulation.  J Clin Endocrinol Metab. 2001;  86 146-150
  • 27 Robinson N, Taroni F, Saugy M, Ayotte C, Mangin P, Dvorak J. Detection of nandrolone metabolites in urine after a football game in professional and amateur players: a Bayesian comparison.  Forensic Sci Int. 2001;  122 130-135
  • 28 Saugy M, Robinson N, Cardis C, Schweizer C, Rivier L, Mangin P, Ayotte C, Dvorak J. Nandrolone metabolites in football players: utility for in and out of competion testing. In: Schanzer W, Geyer H, Gotzmann A, Mareck-Engelke U, eds Recent Avances in Doping Analysis (7), Proceedings of the Manfred Donike Workshop. Köln: Sport und Buch Strauss 1999: 95-108
  • 29 Schmitt N, Flament M M, Goubault C, Legros P, Grenier-Loustalot M F, Denjean A. Nandrolone excretion is not increased by exhaustive exercise in trained athletes.  Med Sci Sports Exerc. 2002;  34 1436-1439
  • 30 Ueki M. Personal communication to Nandrolone Review Committee; Urinary concentrations of 19-norandrosterone in samples collected at the XVIII Winter Olympic Games in 1998. Doping Control Laboratory, Mitsubishi Kagaku Bio-Clinical Labs, Tokyo, Japan letter dated 9 April 2001
  • 31 van der Veen A MH. Measurement of uncertainty and doping in sports: an example. ILAC/IIAF Conference. Berlin September 23 - 25, 2002
  • 32 van Eenoo P, Delbeke F T, de Jong F H, de Backer P. Endogenous origin of norandrosterone in female urine: indirect evidence for the production of 19-norsteroids as by-products in the conversion from androgen to estrogen.  J Steroid Biochem Mol Biol. 2001;  78 351-357

1 The term “Dietary supplement” is used in this report to describe a variety of products that are marketed for the purpose of enhancing sporting performance.

2 In late pregnancy, urinary 19-norandrosterone may exceed 5 nanograms per millilitre [21].

PhD A. Kicman

Head od Research and Development · Drug Control Centre · King's College London

Franklin-Wilkins Building · 150 Stamford Street · London SE1 9NN · UK

Email: andrew.kicman@kcl.ac.uk