Application of Iminophosphorane-Based Methodologies for the Synthesis of Natural Products

Pilar M. Fresneda; Pedro Molina

doi:10.1055/s-2003-43338

ACCOUNT

Application of Iminophosphorane-Based Methodologies for the Synthesis of Natural Products

Pilar M. Fresneda*, Pedro Molina
Departamento de Química Orgánica, Facultad de Química, Universidad de Murcia, Campus de Espinardo, 30071, Murcia, Spain
Fax: +34(968)364149; e-Mail: pmolina@um.es; e-Mail: fresneda@um.es;

Abstract

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Abstract

Four methodologies based on the aza-Wittig reaction have been used for the preparation of the wide variety of nitrogen-containing natural products. The synthesis of quinoline, β-carboline, pyrimidine, oxazole and imidazole alkaloids, by using these methodologies are presented.

1 Introduction

2 Intramolecular aza-Wittig Reaction

3 Tandem aza-Wittig/Electrocyclic Ring-Closure

4 Tandem aza-Wittig/Heterocumulene-Mediated Annelation

5 Tandem aza-Wittig/Intramolecular Halide Displacement

Key words

iminophosphoranes - heterocumulenes - aza-Wittig reaction - tandem process - alkaloids

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References

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