Does Polymorphism C1377T of the Calcitonin Receptor Gene Determine Bone Mineral Density in Postmenopausal Women?

Abstract

In a cross-sectional study we investigated the potential association between CALCR polymorphism (C1377T) and bone mineral density in 114 postmenopausal women. T homozygotes had higher BMD (g/cm²) at the femoral neck compared with carriers of C allele (p < 0.02, ANCOVA). Means of BMD at the lumbar spine did not differ among the genotypes (ANCOVA). In conclusion, the CALCR gene is associated with bone mass at the femoral neck in postmenopausal women.

Key words

Calcitonin receptor gene - C1377T polymorphism - bone mass - bone remodeling

References

• 1 Braga V, Mottes M, Mirandola S, Lisi V, Malerba G, Sartori L, Bianchi G, Gatti D, Rossini M, Bianchini D, Adami S. Association of CTR and COLIA1 alleles with BMD values in peri and postmenopausal women.  Calcif Tissue Int. 2000;  67 361-366
• 2 Masi L, Becherini L, Colli E, Gennari L, Mansani R, Falchetti A, Becorpi A M, Cepollaro C, Gonnelli S, Tanini A, Brandi M L. Polymorphisms of the calcitonin receptor gene are associated with bone mineral density in postmenopausal Italian women.  Biochem Biophys Res Commun. 1998;  248 190-195
• 3 Nakamura M, Zhang Z Q, Shan L, Hisa T, Sasaki M, Tsukino R, Yokoi T, Kaname A, Kakudo K. Allelic variants of human calcitonin receptor in the Japanese population.  Hum Genet. 1997;  99 38-41
• 4 Taboulet J, Frenkian M. Frendo JL, Feingold N, Jullienne A, de Vernejoul MC. Calcitonin receptor polymorphism is associated with a decreased fracture risk in post-menopausal women.  Hum Mol Genetics. 1998;  7 2129-2133