New Cyclizing Reagent for the Synthesis of 1,3,4-Thiadiazoles

Abstract

A new cyclizing reagent is proposed for the synthesis of 5-unsubstituted 1,3,4-thiadiazoles. The latter are formed in good yields by the reactions of thiohydrazides with diethyl chlorophosphate in DMF.

Key words

oxamic thiohydrazides - diethyl chlorophosphate - phosphorus oxychloride - dimethylformamide - unsubstituted carbamoyl-1,3,4-thiadiazoles

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