Planta Med 2003; 69(10): 956-959
DOI: 10.1055/s-2003-45109
Letter
© Georg Thieme Verlag Stuttgart · New York

Pangelin, an Antimycobacterial Coumarin from Ducrosia anethifolia

Michael Stavri1 , K. T. Mathew2 , Franz Bucar3 , Simon Gibbons1
  • 1Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, London, U.K.
  • 2The Herbarium, Department of Biological Science, Kuwait University, Safat, Kuwait
  • 3Institute for Pharmacognosy, University of Graz, Graz, Austria
Further Information

Publication History

Received: March 10, 2003

Accepted: June 19, 2003

Publication Date:
02 December 2003 (online)

Abstract

The aerial parts of Ducrosia anethifolia afforded the monoterpene glucoside 8-debenzoylpaeoniflorin (1) and the prenylated furanocoumarin pangelin {5-[2′′(R)-hydroxy-3′′-methyl-3′′-butenyloxy]furocoumarin} (2). Their structures were determined by extensive 1- and 2-dimensional NMR studies. Compound 2 demonstrated activity against a panel of fast growing mycobacteria, namely Mycobacterium fortuitum, M. aurum, M. phlei and M. smegmatis and minimum inhibitory concentration (MIC) values ranged from 64 - 128 μg/mL. Whilst compounds 1 and 2 have previously been reported as an antihyperglycaemic component from Paeonia lactiflora, and as a constituent of Angelica pancici, respectively, this is the first report of the full 1H- and 13C-NMR data for these natural products.

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Dr. Simon Gibbons

Centre for Pharmacognosy and Phytotherapy

The School of Pharmacy

University of London

29-39 Brunswick Square

London WC1N 1AX

U.K.

Phone: +44-207-753-5913

Fax: +44-207-753-5909

Email: simon.gibbons@ulsop.ac.uk