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DOI: 10.1055/s-2003-45157
Tanshinone IIA from Salvia miltiorrhiza Inhibits Inducible Nitric Oxide Synthase Expression and Production of TNF-α, IL-1β and IL-6 in Activated RAW 264.7 Cells
This paper was supported by VestibuloCoclear Research Center and a grant No. R01-2001-000-00133-0 from the Basic Research Program of the KOSEF, and also supported by Wonkwang University, 2003Publication History
Received: March 20, 2003
Accepted: August 16, 2003
Publication Date:
09 January 2004 (online)
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Abstract
The inhibitory effects of tanshinone IIA, a diterpene isolated from Salvia miltiorrhiza root, on the production of nitric oxide (NO), interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), and the expression of inducible nitric oxide synthase (iNOS) were investigated in activated RAW 264.7 cells. This compound markedly inhibited the production of NO, IL-1β and TNF-α, and suppressed the expression of iNOS in a dose-dependent manner. These results suggest that the traditional use of S. miltiorrhiza as an anti-inflammatory herbal medicine may be explained, in part, by the inhibition of NO, IL-1β, IL-6 and TNF-α production, and expression of iNOS.
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