Planta Med 2003; 69(11): 1068-1070
DOI: 10.1055/s-2003-45161
Letter
© Georg Thieme Verlag Stuttgart · New York

Isolation of Mangiferin from Bombax malabaricum and Structure Revision of Shamimin

Abdelaaty A. Shahat1 , 2 , Rasmeia A. Hassan1 , Naglaa M. Nazif1 , Sabine Van Miert2 , Luc Pieters2 , Faiza M. Hammuda1 , Arnold J. Vlietinck2
  • 1Department of Pharmaceutical Sciences, National Research Centre, Dokki, Cairo, Egypt
  • 2Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium
Further Information

Publication History

Received: April 8, 2003

Accepted: July 26, 2003

Publication Date:
09 January 2004 (online)

Abstract

Repeated column chromatography of the n-BuOH fraction of the 70 % EtOH of the dried leaves of Bombax malabaricum led to the isolation of mangiferin, a xanthone. Mangiferin was identified by UV, 1H- and 13C-NMR spectroscopy and electrospray mass spectrometry. It was found to be identical to shamimin, a compound for which originally a flavonol structure was proposed, and the structure of which has to be revised.

References

  • 1 Chanda Y R. The Wealth of India, Raw Material. Vol. IX New Delhi; CSIR Hillside Rood 1962: pp. 175-83
  • 2 Bircher W H. Gardens of Hesperides. Cairo; The Anglo-Egyptian Book Shop 1960
  • 3 Nadkarni K M. The Indian Materia Medica. Bombay; Popular Parkashan 1976: pp. 207-9
  • 4 MacDonald Hocking G. A Dictionary of Natural Products. Medford; Plexus Publishing, Inc 1997: p. 119
  • 5 Saleem R, Ahmad M, Hussain S, Qazi A M, Ahmad S I, Qazi M H, Ali M, Faizi S, Akhtar S, Hussain S N. Hypotensive, hypoglycaemic and toxicological studies on the flavonol C-glycoside shamimin from Bombax ceiba .  Planta Med. 1999;  65 331-4
  • 6 Faizi S, Ali M. Shamimin: A new flavonol C-glycoside from leaves of Bombax ceiba .  Planta Med. 1999;  65 383-5
  • 7 Hano Y, Matsumoto Y, Shinohara K, Sun J -Y, Nomura T. Structures of four new isoprenylated xanthones, cudraxanthones L, M, N, and O from Cudrania tricuspidata .  Planta Med. 1991;  57 172-5
  • 8 Wada H, Shimizu Y, Tanaka N, Cambie R C, Braggins J E. Chemical and chemotaxonomical studies of ferns. LXXXVII. Constituents of Trichomanes reniforme .  Chem Pharm Bull. 1995;  43 461-5
  • 9 Aritomi M, Komori T, Kawasai T. Massenspektren von Isomangiferin und Mangiferin sowie verwandter peracetylierter C-Glucoside.  Liebigs Ann Chem. 1970;  734 91-101
  • 10 Faizi S, Muhammad  A. 1H and 13C NMR of acetyl derivatives of shamimin, a flavonol C-glycoside.  Magn Reson Chem. 2000;  38 701-3
  • 11 Hostettmann K, Hostettmann M. Xanthones. In: Dey PM, Harborne JB, editors Methods in Plant Biochemistry Vol. 1 Plant Phenolics. London; Academic Press 1989: pp. 493-508
  • 12 Markham K R. Techniques of Flavonoid Identification. London; Academic Press 1982: pp. 36-51

Dr. A. A. Shahat

Department of Pharmaceutical Sciences

University of Antwerp

Universiteitsplein 1

2610 Antwerp

Belgium

Fax: +32 3 820 27 09

Email: shahat@uia.ua.ac.be