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DOI: 10.1055/s-2003-815024
Der Einsatz von Amisulprid bei Patienten mit Morbus Huntington
Amisulpride in Huntington's DiseasePublication History
Publication Date:
11 October 2005 (online)
![](https://www.thieme-connect.de/media/psychiat-praxis/200507/lookinside/thumbnails/10.1055-s-2003-815024-1.jpg)
Zusammenfassung
Hintergrund: Das Benzamidderivat Amisulprid wird als Neuroleptikum der zweiten Generation mit günstigem Nebenwirkungsprofil beschrieben. Methodik: Wir berichten über vier Patienten mit Morbus Huntington und Zeichen einer Psychose, die mit Amisulprid behandelt wurden. Ergebnisse: Zwei Patienten entwickelten Zeichen eines medikamentös induzierten extrapyramidal-motorischen Syndroms, in allen Fällen war die antipsychotische Therapie erfolgreich. Diskussion: Aufgrund des zunehmenden Untergangs striataler Neurone treten bei Patienten mit M. Huntington auch unter Amisulprid bereits früh extrapyramidal-motorische Nebenwirkungen auf.
Abstract
Objectives: Amisulpride is a substituted benzamide derivative with atypical antipsychotic properties and low side effects. Method: We report four cases of patients with clinically and genetically established Huntington's disease and signs of psychosis who were treated with Amisulpride. Results: Two patients developed extrapyramidal side effects due to the treatment. The antipsychotic therapy of all patients was effective. Discussion: Due to degeneration of striatal neurons patients suffering from Huntington's disease react early with development of extrapyramidal side effects after therapy with amisulpride.
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Dr. med. Carsten Saft
Neurologische Klinik der Ruhr-Universität Bochum · St. Josef-Hospital · Huntington Zentrum NRW
Gudrunstraße 56
44791 Bochum
Email: carsten.saft@cityweb.de