¹³C-basierte Atemtests in der Leberfunktionsdiagnostik

Zusammenfassung

Konventionelle laborchemische Surrogatparameter geben indirekte Hinweise auf den Metabolismus oder die Syntheseleistung hepatischer Zellsysteme. ¹³C-basierte Atemtests erweitern das diagnostische Spektrum um die Aussicht, Enzymsysteme und medikamentöse Interaktionen relativ gezielt nichtinvasiv charakterisieren zu können. Wir geben einen Überblick über die bisher verfügbaren verschiedenen Testsysteme sowie den möglichen Stellenwert in der hepatologischen Diagnostik.

Abstract

Routine work-up of hepatic diseases is performed by regular laboratory tests which indicate changes in the metabolic capacity of various hepatic cellular systems. A ¹³C-based breath test may offer further selective characterisation of hepatic enzymes by means of a non-invasive technique. We present an overview on current test systems and their potential relevance in the assessment of hepatic diseases.

Leberfunktion - Atemtest - stabile Isotope - Hepatitis - Leberzirrhose - Fibrose

Liver function - breath test - stable isotopes - hepatitis - liver cirrhosis - fibrosis

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