Zusammenfassung
Die echosignalverstärkte Sonographie kann zur Differenzialdiagnostik von Pankreasraumforderungen eingesetzt werden. In der vorliegenden Arbeit wird anhand von Fallbeispielen auf die Kriterien zur Unterscheidung von zystischen Pankreastumoren mit diesem Verfahren eingegangen.
Zystadenome weisen gewöhnlich viele Gefäße auf, die entlang von Bindegewebssepten verlaufen. Zystadenokarzinome sind dagegen meistens durch ein chaotisches und wenig ausgeprägtes Gefäßnetz gekennzeichnet. „Junge Pseudozysten” zeigen oft eine deutliche Wandhyperämie, die Wandbegrenzungen „älterer Pseudozysten” sind wenig durchblutet. Schlussfolgerung: Zystische Pankreasläsionen zeigen in der echosignalverstärkten Sonographie unterschiedliche Vaskularisationsmuster. Das kann für ihre Differenzialdiagnostik von Bedeutung sein. Goldstandard ist und bleibt aber die Histologie.
Abstract
Echo-enhanced sonography is useful for differential diagnosis of pancreatic tumours. We present several criteria for the differentiation of cystic pancreatic lesions with this procedure using three selected patients.
Cystadenomas frequently show many vessels along the fibrotic strands. On the other hand, cystadenocarcinomas are poorly and chaotically vascularised. “Young pseudocysts” frequently show a highly vascularised wall. However, the wall of “old pseudocysts” is poorly vascularised. Conclusion : Cystic pancreatic masses have a different vascularisation pattern when examined by echo-enhanced sonography. These characteristics can be useful for their differential diagnosis, but histology is still the “gold standard.”
Schlüsselwörter
Zystische Pankreastumoren - Differenzialdiagnostik - echosignalverstärkte Sonographie
Key words
Cystic pancreatic lesions - differential diagnosis - echo-enhanced sonography
References
1
Fernandez-del Castillo C, Warshaw A L.
Cystic tumours of the pancreas.
Surg Clin North Am.
1995;
75
1001-1016
2
Compagno J, Oertel J E.
Microcystic adenomas of the pancreas (glycogen-rich cystadenomas). A clinopathological study of 34 cases.
Am J Clin Pathol.
1978;
69
289-298
3
Compagno J, Oertel J E.
Mucinous cystic neoplasms of the pancreas with overt and latent malignancy (cystadenocarcinoma and cystadenoma). A clinopathological study of 41 cases.
Am J Clin Pathol.
1978;
69
573-580
4
Warshaw A L, Compton C C, Lewandrowsky K. et al .
Cystic tumours of the pancreas.
Ann Surg.
1990;
212
432-445
5
Torressan F, Casadei R, Solmi L. et al .
The role of ultrasound in the differential diagnosis of serous and mucinous cystic tumours of the pancreas.
Eur J Gastroenterol Hepatol.
1997;
9
169-172
6
Yang Y ET, Joehl R J, Talamonti R S.
Cystic neoplasms of the pancreas.
J Am Coll Surg.
1994;
179
747-757
7
De Calan L, Levard H, Hennet H. et al .
Pancreatic cystadenoma and cystadenocarcinoma: diagnostic value of preoperative morphological investigations.
Eur J Surg.
1995;
161
35-40
8
Rickes S, Unkrodt K, Neye H. et al .
Differentiation of pancreatic tumours by conventional ultrasound, unenhanced and echo-enhanced power Doppler sonography.
Scand J Gastroenterol.
2002;
37
1313-1320
9
Rickes S, Unkrodt K, Ocran K. et al .
Differentiation of neuroendocrine tumours from other pancreatic lesions by echo-enhanced power Doppler sonography and somatostatin receptor scintigraphy.
Pancreas.
2003;
26
76-81
10
Rickes S, Unkrodt K, Wermke W. et al .
Evaluation of dopplersonographic criteria for the differentiation of pancreatic tumours.
Ultraschall Med.
2000;
20
253-258
11
Rickes S, Flath B, Wermke W. et al .
Pancreatic metastases of renal cell carcinomas - evaluation of the contrast behaviour at echo-enhanced power Doppler sonography in comparison to primary pancreatic tumours.
Z Gastroenterol.
2001;
39
571-578
12
Bunk A, Herzog K H, Kunze P. et al .
Sonographisch-differentialdiagnostische Aspekte beim Zystadenom des Pankreas.
Ultraschall Med.
1995;
16
210-217
13
Le Borgne J, de Calan L, Partensky C. and the French Surgical Association .
Cystadenomas and cystadenocarcinomas of the pancreas. A multiinstitutional retrospective study of 398 cases.
Ann Surg.
1999;
130
152-161
14
Fugazzola C, Procacci C, Bergamo Andreis I A. et al .
Cystic tumours of the pancreas: evolution by ultrasonography and computed tomography.
Gastrointest Radiol.
1991;
16
53-61
15
Goldstein H M, Neiman H L, Bookstein J J.
Angiography evaluation of pancreatic disease. A further appraisal.
Radiology.
1974;
112
275-282
16
Reuter S R, Redman H C, Bookstein J J.
Differential diagnosis of carcinoma of the pancreas.
Radiology.
1970;
96
93-99
17
Appleton G V, Bathurst N C, Virjee J. et al .
The value of angiography in the surgical management of pancreatic disease.
Ann R Coll Surg Engl.
1989;
71
92-96
18 Wermke W, Gaßmann B. Tumour diagnostics of the liver with echo enhancers. Berlin/Heidelberg/New York; Springer Verlag 1998
19
Calliada F, Campani R, Bottinelli O. et al .
Ultrasound contrast agents. Basic principles.
Eur J Radiol.
1998;
27
157-160
20
Correas J M, Hélénon O, Pourcelot L. et al .
Ultrasound contrast agents. Examples of blood pool agents.
Acta Radiologica.
1997;
38
101-112
21
Kim A Y, Choi B I, Kim T K. et al .
Comparison of contrast-enhanced fundamental imaging, second-harmonic imaging, and pulse-inversion harmonic imaging.
Invest Radiol.
2001;
36
582-588
22
Rickes S, Wermke W.
Differentiation of cystic pancreatic neoplasms and pseudocysts by echo-enhanced sonography.
Gastroenterology.
2003;
124 (suppl. 1)
174
Dr. Steffen Rickes
Otto-von-Guericke-University Magdeburg, Dept. of Gastroenterology, Hepatology and Infectiology
Leipziger Str. 44
39120 Magdeburg
Germany
eMail: steffen.rickes@medizin.uni-magdeburg.de