Syntheses of Some 4-Anilinoquinazoline Derivatives

Abstract

Some 4-N-(3′- or 4′-substituted-phenyl)amino-6,7-dimethoxyquinazolines and the corresponding unsubstituted compounds were synthesized from 2-amino-4,5-dimethoxybenzoic acid and the appropriate substituted anilines. Other related quinazolines or their synthetic intermediates were also obtained. A large number of the described quinazolines are new compounds, while the remaining were prepared by a more efficient procedure. The main goal for the synthesis of these compounds comes from the fact that the 4-anilinoquinazoline pharmacophore is an important unit, which is found among the ATP-competitive inhibitors of several protein kinase enzymes.

Key words

4-anilinoquinazolines - quinazolinones - ATP-inhibitors

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Franchini, K., Faculty of Medical Sciences, State University of Campinas, personal communication.