A Mild and Efficient Procedure for the Synthesis of 1-(Alkyldithiocarbonyl)-imidazoles

Yi-Qiang Wang; Ze-Mei Ge; Xue-Ling Hou; Tie-Ming Cheng; Run-Tao Li

doi:10.1055/s-2004-815972

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Synthesis 2004(5): 675-678
DOI: 10.1055/s-2004-815972

PAPER

A Mild and Efficient Procedure for the Synthesis of 1-(Alkyldithiocarbonyl)-imidazoles

Yi-Qiang Wang, Ze-Mei Ge, Xue-Ling Hou, Tie-Ming Cheng, Run-Tao Li*
School of Pharmaceutical Sciences, Peking University, Beijing 100083, P. R. China
Fax: +86(10)62346154; e-Mail: lirt@mail.bjmu.edu.cn;

Further Information

Publication History

Received 28 November 2003
Publication Date:
12 February 2004 (online)

Abstract
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Abstract

1-(Alkyldithiocarbonyl)-imidazoles, 1-(methyldithio- carbonyl)-1,2,4-triazole and 1-(methyldithiocarbonyl)-benzotriazole were prepared in good to excellent yields from the reaction of imidazol, 1,2,4-1H-triazole and 1H-benzotriazole with carbon disulfide and corresponding alkylating agents in the presence of anhydrous potassium phosphate in acetone at room temperature within 2 hours.

Key words

1-(alkyldithiocarbonyl)-imidazole - thiocarbonyl transfer reagent - synthesis - anhydrous potassium phosphate - imidazole

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