Kaurane-Type Diterpene Glycoside from the Stem Bark of Acanthopanax trifoliatus

Phan Van Kiem; Xing Fu Cai; Chau Van Minh; Jung Joon Lee; Young Ho Kim

doi:10.1055/s-2004-818926

Planta Medica, Table of Contents

Planta Med 2004; 70(3): 282-284
DOI: 10.1055/s-2004-818926

Letter

Kaurane-Type Diterpene Glycoside from the Stem Bark of Acanthopanax trifoliatus

Phan Van Kiem¹ , Xing Fu Cai² , Chau Van Minh¹ , Jung Joon Lee³ , Young Ho Kim²

¹Institute of Natural Products Chemistry, NCST, Nghiado, Caugiay, Hanoi, Vietnam
²College of Pharmacy, Chungnam National University, Taejon, Korea
³Korea Research Institute of Bioscience and Biotechnology, Yusong, Daejeon, Korea

This study was supported by a grant from the Korea-Vietnam international cooperation project by the Ministry of Science and Technology, in Korea

Abstract

A new diterpene glycoside, acantrifoside D (1), as well as three known diterpenes (2 - 4) were isolated from the stem bark of Acanthopanax trifoliatus from Vietnam. Based on 1D and 2D NMR spectroscopic data, their chemical structures were determined to be 16α,17-dihydroxy-ent-kauran-19-oic acid 16-O-β-D-glucopyranoside 19-O-β-D-glucopyranosyl ester (1), 16αH,17-isovalerate-ent-kauran-19-oic acid (2), ent-kaur-16-en-19-oic acid (3), and ent-pimara-8(14),15-dien-19-oic acid (4). Compounds 2 - 4 had strong inhibitory effects against COX-1 in an in vitro assay, with IC₅₀ values of 0.21, 0.15 and 0.19 mM, respectively.

Full Text

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Young Ho Kim Ph. D.

College of Pharmacy

Chungnam National University

Taejon 305-764

Korea

Phone: +82-42-821-5933

Fax: +82-42-823-6566

Email: yhk@cnu.ac.kr