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Planta Med 2004; 70(5): 437-440
DOI: 10.1055/s-2004-818972
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag KG Stuttgart · New York

Antiplasmodial Agents from the Leaves of Glossocalyx brevipes

James A. Mbah1 , Pierre Tane1 , Bonaventure T. Ngadjui2 , Joseph D. Connolly3 , Christopher C. Okunji4 , Maurice M. Iwu4 , Brian M. Schuster4
  • 1Chemistry Department, Faculty of Science, University of Dschang, Dschang, Cameroon
  • 2Organic Chemistry Department, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon
  • 3Department of Chemistry, University of Glasgow, Glasgow, Scotland
  • 4Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, DC, USA
We gratefully acknowledge financial support from the ICBG ”Drug Development and Conservation in West and Central Africa” Grant No TW01023 - 01-AP2 from the Fogarty Center, NIH, and from the International Science Program (ISP), Grant No CAM:02, Uppsala University, Sweden
Further Information

Publication History

Received: August 5, 2003

Accepted: February 16, 2004

Publication Date:
04 May 2004 (online)

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Abstract

A phytochemical study of the methylene chloride/methanol (1/1) extract of the leaves of Glossocalyx brevipes Benth. (Monimiaceae) afforded three new derivatives of homogentisic acid, methyl 2-(1′β-geranyl-5′β-hydroxy-2′-oxocyclohex-3′-enyl)acetate (1), 2-(1′β-geranyl-5′β-hydroxy-2′-oxocyclohex-3′-enyl)acetic acid (2), methyl 2-(1′β-geranyl-5′β-hydroxy-4′β-methoxy-2′-oxocyclohexyl)acetate (3), and two known alkaloids, aristololactam BII and liriodenine. Compounds 1 and 2 and liriodenine showed modest in vitro activity against Plasmodium falciparum.

Key words

Glossocalyx brevipes - Monimiaceae - homogentisic acid derivatives - liriodenine - antiplasmodial activity

References

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Prof. Pierre Tane

Department of Chemistry

Faculty of Science

University of Dschang

Box 67

Dschang

Cameroon

Fax: +237-345-1202

Email: ptane@yahoo.com