Nor-lignans and Steroidal Saponins from Asparagus gobicus

Abstract

From the roots of Asparagus gobicus, four new nor-lignans, 3′-methoxynyasin, iso-agatharesinol, gobicusins A, B and one new steroidal saponin, 3-O-[β-D-xylopyranosyl(1 - 4)-β-D-glucopyranosyl(1 - 2)-β-D-glucopyranosyl]-(25S)-5β-spirostan-3β-ol (11) were isolated, together with twelve known compounds. The structures of the new compounds were established by spectroscopic methods including 2D-NMR techniques (¹H-¹H COSY, HMBC, HMQC) and chemical transformations. Nyasol (5) and 11 exhibited remarkable in vitro cytotoxic activity against cultured HO-8910 (human ovarian carcinoma) and Bel-7402 (human hepatoma) cells with IC₅₀ vales of 30.6 and 29.4 μM, 5.2 and 5.2 μM, respectively.

Asparagus gobicus - Asparagaceae - nor-lignans - steroidal saponins - cytotoxic activity

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