Abstract
The EtOH extract of gardenia (Gardenia jasminoides Ellis) fruits was previously found to possess potent anti-angiogenic activity in the chick embryo chorioallantoic membrane (CAM) assay. Bioassay-guided fractionation and purification of the EtOH extract yielded an active anti-angiogenic compound, which was determined to be an iridoid glucoside, geniposide, by spectral analyses. Geniposide showed anti-angiogenic activity in a dose-dependent manner. It also exhibited an inhibitory effect in the range of 25 - 100 μM on the growth of the transformed NIH3T3 cell line.
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Prof. Eun-Hee Park
College of Pharmacy
Sookmyung Women's University
Cheongpa-dong
Yongsan
Seoul 140-742
South Korea
Phone: +82-2-710-9565
Fax: +82-2-3273-5847
Email: ehpark@sookmyung.ac.kr
