Summary
An enlargement of the thyroid gland is often found in patients with breast cancer and fibrocystic disease. Experimental analysis in animals shows that iodine deficiency causes proliferations and dysplasia in the mammary gland similar to human fibrocystic disease. Elemental iodine supplementation can stop and partially lead to an involution of the mammary proliferations and dysplasia. Probably iodolactones are involved in the process of involution, similar to thyroid gland. The basis for iodolactone production in the mammary gland is given. Like the thyroid gland, the mammary gland can concentrate iodide by expressing the sodium/iodide symporter, the cell membrane transport protein. The sodium/iodide symporter is not only expressed during lactation but also in fibrocystic disease and in the majority of breast cancers. Iodolactones are synthesized with the mammary enzyme lactoperoxidase, an enzyme that is used for the pharmacological synthesis of iodolactones. Iodolactones can inhibit the EGF-receptor, thereby playing an important role in the pathophysiology of breast cancer and fibrocystic disease. Using the sodium/iodide symporter there are new options for the therapy of metastatic breast cancer.
Beitrag in Volltext: https://www.thieme-connect.de/ejournals/html/10.1055/s-2004-820575
Full text article: https://www.thieme-connect.de/ejournals/html/10.1055/s-2004-834453
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