Synthesis 2004(6): 942-948  
DOI: 10.1055/s-2004-822321
PAPER
© Georg Thieme Verlag Stuttgart · New York

A Simple One-Pot Synthesis of 2,6-Disubstituted 4-(Polyfluoroalkyl)pyridines and -pyrimidines by Reaction of 2-Polyfluoroalkylchromones with Aromatic Methyl Ketimines and Amidines

Vyacheslav Ya. Sosnovskikh*, Boris I. Usachev, Aleksei Yu. Sizov, Mikhail A. Barabanov
Department of Chemistry, Ural State University, 620083 Ekaterinburg, Russian Federation
Fax: +7(3432)615978; e-Mail: Vyacheslav.Sosnovskikh@usu.ru;
Further Information

Publication History

Received 4 February 2004
Publication Date:
25 March 2004 (online)

Abstract

The reaction of 2-polyfluoroalkylchromones with ketimines, derived from aromatic methyl ketones and isopropyl­amine, gives 2,6-diaryl-4-polyfluoroalkylpyridines in moderate to low yields. Benzamidine and guanidine also react with 2-polyfluoroalkylchromones to afford the corresponding 2,6-disubstituted 4-polyfluoroalkylpyrimidines.