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Synthesis 2004(12): 2058-2061
DOI: 10.1055/s-2004-822327
DOI: 10.1055/s-2004-822327
PSP
© Georg Thieme Verlag Stuttgart · New York
Ring-Closing Metathesis of Vinyl Chlorides for Formation of 5-, 6- and 7-Membered Carbocyclic and Heterocyclic Systems
Further Information
Publication History
Received
12 January 2004
Publication Date:
02 April 2004 (online)


Abstract
Ring-closing metathesis (RCM) of olefinic vinyl chlorides can be effected using the second generation Grubb’s catalyst 18 (10 mol%, deoxygenated benzene, 65 °C) to assemble a variety of carbocyclic and heterocyclic 5, 6 and 7-membered rings in high yields.
Key words
ring-closing metathesis reactions - annulations - vinyl chlorides - Grubbs ruthenium alkylidene catalyst