Ring-Closing Metathesis of Vinyl Chlorides for Formation of 5-, 6- and 7-Membered Carbocyclic and Heterocyclic Systems

Wenchun Chao; Matthew L. Meketa; Steven M. Weinreb

doi:10.1055/s-2004-822327

PSP

Ring-Closing Metathesis of Vinyl Chlorides for Formation of 5-, 6- and 7-Membered Carbocyclic and Heterocyclic Systems

Wenchun Chao, Matthew L. Meketa, Steven M. Weinreb*
Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
Fax: +1(814) 8638403; e-Mail: smw@chem.psu.edu;

Abstract

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Abstract

Ring-closing metathesis (RCM) of olefinic vinyl chlorides can be effected using the second generation Grubb’s catalyst 18 (10 mol%, deoxygenated benzene, 65 °C) to assemble a variety of carbocyclic and heterocyclic 5, 6 and 7-membered rings in high yields.

Key words

ring-closing metathesis reactions - annulations - vinyl chlorides - Grubbs ruthenium alkylidene catalyst

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References

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