Planta Med 2004; 70(9): 869-870
DOI: 10.1055/s-2004-827238
Letter
© Georg Thieme Verlag KG Stuttgart · New York

A New VHR Dual-Specificity Protein Tyrosine Phosphatase Inhibitor from Dendrobium moniliforme

Eun Young Bae1 , 4 , Hyuncheol Oh1 , 4 , Won Keun Oh1 , Min Soo Kim1 , Beom Seok Kim1 , Bo Yeon Kim1 , Cheon Bae Sohn2 , Hiroyuki Osada3 , Jong Seog Ahn1
  • 1Korea Research Institute of Bioscience and Biotechnology (KRIBB), Taejeon, South Korea
  • 2Department of Food and Nutrition, Chungnam National University, Taejeon, South Korea
  • 3The Institute of Physical and Chemical Research (RIKEN), Wako-shi, Saitama, Japan
  • 4These authors contributed equally to the work
Further Information

Publication History

Received: February 27, 2004

Accepted: May 15, 2004

Publication Date:
23 September 2004 (online)

Abstract

Bioassay-guided fractionation of the EtOAc-soluble extract of Dendrobium moniliforme afforded a new phenanthraquinone-type metabolite, 7-hydroxy-5,6-dimethoxy-1,4-phenanthrenequinone (1), along with the previously reported 5-hydroxy-3,7-dimethoxy-1,4-phenanthrenequinone (2). The structures of the compounds were identified mainly on the basis of MS and NMR data. Compound 1 inhibited VHR dual-specificity protein tyrosine phosphatase (DS-PTPase) activity in a dose-dependent manner, displaying an IC50 value of 3.0 ± 0.2 μM.

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Dr. Jong Seog Ahn

Korea Research Institute of Bioscience and Biotechnology (KRIBB)

52 Eoeun-dong

Yusong

Taejeon 305-333

Korea

Fax: +82-42-860-4595

Email: jsahn@kribb.re.kr