Zusammenfassung
Mittels Positronenemissionstomographie (PET) sollten zerebrale Regionen identifiziert werden, in denen sich Demenzen aus der Gruppe der frontotemporalen lobären Degenerationen (FTLD) in ihrem Glukosestoffwechsel von der Alzheimer-Krankheit (AD) unterscheiden. Es wurden je 14 Patienten mit der klinischen Diagnose FTLD bzw. AD untersucht. Signifikante Unterschiede zeigten sich in der linken Insula, im Gyrus frontalis medialis beidseits und im rechten Gyrus temporalis medialis. Die PET könnte daher ein viel versprechender Baustein bei der Differenzialdiagnose dieser demenziellen Syndrome sein.
Abstract
Objective: To describe differences in cerebral glucose metabolism between frontotemporal lobar degeneration (FTLD) and Alzheimer's disease (AD). Methods: 14 patients with FTLD (7 f/7 m, mean age 60.1 years) and 14 patients with AD (7 f/7 m, mean age 59.5 years) were examined. [18F]FDG positron emission tomography (PET) scans were analysed with statistical nonparametric mapping (SnPM) and statistical parametric mapping (SPM99). Results: Significant decreases in glucose metabolism in FTLD compared to AD were detected in the left insula/left inferior frontal gyrus (Brodman area [BA]13, 45 and 47) and in the medial frontal gyrus bilaterally (BA10). A significant decrease in AD compared to FTLD was identified in the right middle temporal gyrus (BA39). Conclusion: Cerebral PET could be a promising tool to discriminate FTLD from AD.
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Stefan Poljansky
Bezirksklinikum Regensburg
Universitätsstraße 84
93053 Regensburg
Email: stefan.poljansky@medbo.de
