Adipocytokines: Fat-Derived Humoral Mediators of Metabolic Homeostasis

H. Staiger; H.-U. Häring

doi:10.1055/s-2004-830555

Experimental and Clinical Endocrinology & Diabetes, Table of Contents

Exp Clin Endocrinol Diabetes 2005; 113(2): 67-79
DOI: 10.1055/s-2004-830555

Review

J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Adipocytokines: Fat-Derived Humoral Mediators of Metabolic Homeostasis

H. Staiger¹ , H.-U. Häring¹

¹Department of Endocrinology, Metabolism, and Pathobiochemistry, Medical Clinic Tübingen, Eberhard-Karls-University, Tübingen, Germany

Abstract

The metabolic syndrome currently reaches epidemic proportions in the Western industrialized world. Its hallmarks obesity, type 2 diabetes mellitus, and atherosclerosis are closely associated, and we are just beginning to understand the reasons for this relationship: adipose tissue-derived proteohormones (adipocytokines), under normal weight conditions, guarantee homeostasis of glucose and lipid metabolism, but their dysregulated production in the obese state promotes insulin resistance, inflammation, as well as atherosclerotic events. This review will focus on the current understanding of the adipocytokines' molecular role in metabolism and metabolic disease.

Key words

Adipocytokines - insulin sensitivity - metabolism - obesity

Full Text

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